Buffalo Bills vs. Indianapolis Colts early prediction: Indy’s .500 chances thwarted by Josh Allen, Bills

The Buffalo Bills will battle the Indianapolis Colts in Week 10 of the NFL season at Lucas Oil Stadium this Sunday, scheduled to begin at 1 p.m. EST. Joe Flacco once again gets the nod at quarterback for the Colts, despite a poor performance last week that produced season-lows for the team in points, yards, and first downs. Meanwhile, Josh Allen and the Bills will look to secure their fifth straight victory and cement their status as the best team in the AFC East.
In preparation for this midseason clash, the data analysts at Dimers.com have simulated the game 10,000 times, and then compared these results to current NFL betting odds to inform the data-driven betting preview provided to you below.
This preview includes Dimers’ best bets and predicted scoreline for Buffalo Bills vs. Indianapolis Colts. To unlock Dimers’ full suite of data-driven betting insights, which includes daily props, trends, and parlays, sign up for Dimers Pro with promo code SYRACUSE10, which will save you 10% off your first subscription payment.
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Utilize the interactive widget below to view the current spread, over/under, and moneyline betting odds and probabilities for the Bills-Colts game at Lucas Oil Stadium.
This prediction and best bet for Sunday’s NFL matchup between the Bills and Colts is from Dimers.com, a leader in sports betting predictions.
Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.
The key information you need before the Bills vs. Colts NFL game.
Odds for the key markets in the Bills-Colts NFL game.
The odds and lines featured in this article are the best available from selected sports betting site at the time of publication and are subject to change.
Utilizing cutting-edge data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Bills vs. Colts game.
According to Dimers’ popular predictive analytics model, the Bills are more likely to beat the Colts at Lucas Oil Stadium. This prediction is based on the model giving the Bills a 57% chance of winning the game.
Furthermore, Dimers predicts that the bookies have got it right and the Bills and Colts each have a 50% chance of covering the spread, while the 46.5-point over/under has a 53% chance of staying under.
These predictions and probabilities are correct at the time of publication but are subject to potential changes.
Our top pick for the Bills vs. Colts Week 10 NFL game is to bet on Under 46.5 points (-110).
This betting advice is formulated through detailed modeling and valuable betting intelligence, designed to assist you in making more informed investments.
Dimers’ projected final score for the Buffalo vs. Indianapolis game on Sunday has the Bills prevailing 23-21.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
Get ready for Sunday’s matchup between the Bills and Colts in Week 10 of the NFL season at Lucas Oil Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Bills vs. Colts matchup, and they are correct at the time of publishing to help you make better decisions when placing bets at online sportsbooks.
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